Ingredient guide
Tripeptide-5 (Syn-Coll)
INCI name · tripeptide-5
In short
Tripeptide‑5 (Syn‑Coll) is a well‑known signal peptide studied for its ability to support collagen pathways and improve the look of skin texture. It is water‑soluble, stable, and used in many peptide serums.
What it is
Signal peptide that mimics the natural thrombospondin-1 activation of TGF-β1, stimulating collagen I synthesis in fibroblasts; clinically studied under the name Syn-Coll at 2% concentration showing statistically significant reductions in measured skin roughness versus vehicle; water-soluble and stable across typical serum and moisturiser pH ranges; well tolerated in human repeat insult patch testing.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Tripeptide-5
- Moisturise
- SPF
Also found as
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Common questions
What does Tripeptide‑5 do for skin?
It helps improve the appearance of firmness and smoothness by supporting collagen‑related signalling.
Is Tripeptide‑5 good for most skin types?
Yes, it is generally well tolerated and fits into most routines, including sensitive‑leaning skin.
How is Tripeptide‑5 used?
It appears in serums and moisturisers designed for texture refinement and elasticity support.
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Personal guidance, not medical advice.