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Ingredient guide
tripeptide-5
In short
Tripeptide‑5 (Syn‑Coll) is a well‑known signal peptide studied for its ability to support collagen pathways and improve the look of skin texture. It is water‑soluble, stable, and used in many peptide serums.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Firmness · Texture
Best used
Evening
What it is
Signal peptide that mimics the natural thrombospondin-1 activation of TGF-β1, stimulating collagen I synthesis in fibroblasts; clinically studied under the name Syn-Coll at 2% concentration showing statistically significant reductions in measured skin roughness versus vehicle; water-soluble and stable across typical serum and moisturiser pH ranges; well tolerated in human repeat insult patch testing.
Also found as
Related
Where to find it
Derma E Firming DMAE Moisturizer
Peter Thomas Roth Un-Wrinkle Turbo Face Serum
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Common questions
It helps improve the appearance of firmness and smoothness by supporting collagen‑related signalling.
Yes, it is generally well tolerated and fits into most routines, including sensitive‑leaning skin.
It appears in serums and moisturisers designed for texture refinement and elasticity support.
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Personal guidance only · For clinical concerns, see a dermatologist.