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Ingredient guide
octapeptide-4
In short
Octapeptide‑4 is a collagen‑signalling peptide that encourages a firmer, smoother feel. It works by mimicking part of collagen’s natural structure to prompt fibroblasts to stay active.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Firmness · Texture
Best used
Evening
What it is
Eight amino acid peptide that mimics the C-terminal domain of type I collagen propeptide to signal collagen synthesis in dermal fibroblasts; the KGS and KPG motifs interact with SPARC (secreted protein, acidic, and rich in cysteine) and matrix metalloproteinase binding sites on the fibroblast surface; in vitro data suggests upregulation of collagen types I, III, and IV at 1–5 ppm; most effective in combination with antioxidants such as vitamin C or ferulic acid that protect newly synthesised collagen from oxidative degradation.
Also found as
Related
Common questions
It supports a more elastic, refined appearance by encouraging collagen‑related activity.
It suits those looking to improve firmness or texture.
It usually appears in targeted serums and can be layered with hydrating or antioxidant formulas.
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Personal guidance only · For clinical concerns, see a dermatologist.