Ingredient guide
Octapeptide-4
INCI name · octapeptide-4
In short
Octapeptide‑4 is a collagen‑signalling peptide that encourages a firmer, smoother feel. It works by mimicking part of collagen’s natural structure to prompt fibroblasts to stay active.
What it is
Eight amino acid peptide that mimics the C-terminal domain of type I collagen propeptide to signal collagen synthesis in dermal fibroblasts; the KGS and KPG motifs interact with SPARC (secreted protein, acidic, and rich in cysteine) and matrix metalloproteinase binding sites on the fibroblast surface; in vitro data suggests upregulation of collagen types I, III, and IV at 1–5 ppm; most effective in combination with antioxidants such as vitamin C or ferulic acid that protect newly synthesised collagen from oxidative degradation.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Octapeptide-4
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does Octapeptide‑4 do for skin?
It supports a more elastic, refined appearance by encouraging collagen‑related activity.
Who is Octapeptide‑4 for?
It suits those looking to improve firmness or texture.
How is Octapeptide‑4 used?
It usually appears in targeted serums and can be layered with hydrating or antioxidant formulas.
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Personal guidance, not medical advice.