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Ingredient guide
heptapeptide-1
In short
Heptapeptide‑1, known as Melanostatine, is a tone‑evening peptide that works upstream in the melanin‑forming pathway. It helps reduce the look of uneven pigmentation caused by sun exposure or post‑inflammation.
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Works for
Tone
Best used
Morning
What it is
Commercially Melanostatine (Lipotrue); competitive antagonist at MC1R (melanocyte-stimulating hormone receptor); prevents alpha-MSH receptor binding → downstream reduction in cAMP → reduced MITF expression → reduced tyrosinase activity and melanin synthesis; brightening mechanism is upstream of tyrosinase, distinct from kojic acid or arbutin; suited to post-inflammatory hyperpigmentation and UV-induced uneven tone.
Also found as
Related
Common questions
It interferes with signals that normally trigger melanin production, helping dark spots appear less pronounced over time.
It suits people dealing with uneven tone, including areas affected by past sun exposure or post‑inflammatory marks.
It is found in brightening serums or creams, often alongside ingredients like niacinamide or gentle exfoliants.
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Personal guidance only · For clinical concerns, see a dermatologist.