Ingredient guide
Heptapeptide-1 (Melanostatine)
INCI name · heptapeptide-1
In short
Heptapeptide‑1, known as Melanostatine, is a tone‑evening peptide that works upstream in the melanin‑forming pathway. It helps reduce the look of uneven pigmentation caused by sun exposure or post‑inflammation.
Works forFrom reviewed ingredient data
Best used
Morning
What it is
Commercially Melanostatine (Lipotrue); competitive antagonist at MC1R (melanocyte-stimulating hormone receptor); prevents alpha-MSH receptor binding → downstream reduction in cAMP → reduced MITF expression → reduced tyrosinase activity and melanin synthesis; brightening mechanism is upstream of tyrosinase, distinct from kojic acid or arbutin; suited to post-inflammatory hyperpigmentation and UV-induced uneven tone.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Mornings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Heptapeptide-1
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does Heptapeptide‑1 do for skin?
It interferes with signals that normally trigger melanin production, helping dark spots appear less pronounced over time.
Who can use Heptapeptide‑1?
It suits people dealing with uneven tone, including areas affected by past sun exposure or post‑inflammatory marks.
How is Heptapeptide‑1 used in skincare?
It is found in brightening serums or creams, often alongside ingredients like niacinamide or gentle exfoliants.
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Personal guidance, not medical advice.