Ingredient guide
Hexapeptide-1
INCI name · hexapeptide-1
In short
Hexapeptide‑1 is a peptide that interacts with the skin’s melanin‑signalling pathway, helping to moderate pigment formation. It is often used alongside other brightening ingredients for a more even-looking tone.
What it is
Hexapeptide that acts as a competitive antagonist of α-MSH (alpha-melanocyte-stimulating hormone) at the MC1R receptor on melanocytes, reducing cyclic AMP-mediated induction of tyrosinase and MITF; the mechanism is upstream of tyrosinase inhibitors such as kojic acid or arbutin, targeting the transcriptional pathway before enzyme synthesis; may complement downstream tyrosinase inhibitors in a multi-pathway brightening regimen; peptide approach reduces the risk of irritation seen with some small-molecule brighteners.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Mornings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Hexapeptide-1
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does Hexapeptide‑1 do?
It helps reduce the appearance of uneven tone by acting early in the melanin‑signalling process.
Who can use Hexapeptide‑1?
Most skin types can use it, especially those aiming for a more uniform-looking complexion.
How is Hexapeptide‑1 used in skincare?
It is commonly added to brightening serums or spot-fading formulas and layers well with other tone-evening ingredients.
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Personal guidance, not medical advice.