MIRU
Evidence recordApplied to skin
Hyaluronic acid (topical)
Answer
One 60-day, 0.1% periocular study reported hydration and elasticity improvements across the tested molecular weights; wrinkle-depth improvement was limited to the 50 and 130 kDa arms.
Check the formulaEvidence grade
Moderate
Useful human evidence supports the claim, with a meaningful limit in scale, duration, formulation or consistency.
Where it stops
Not stated in this record yet
Sources
Sources · 1
Source 1
J Drugs Dermatol, 2011- Design
- Split-area, vehicle-controlled study
- Participants
- 76
- Duration
- 60 days
- Reported numbers
- 0.1%
- Measured outcome
- periocular hydration, periocular elasticity, periocular wrinkle depth
- Studied formulation
- 0.1% hyaluronan at 50, 130, 300, 800 or 2,000 kDa
Finding
Split-area, vehicle-controlled study in 76 women over 60 days: all five 0.1% periocular hyaluronan preparations improved measured hydration and elasticity versus vehicle; wrinkle-depth improvement was reported only for the 50 and 130 kDa arms. The paper’s penetration explanation is speculative, not a demonstrated outcome.