{
  "id": "hyaluronic-acid",
  "idVersion": 1,
  "ingredient": "Hyaluronic acid (topical)",
  "route": "topical",
  "grade": "moderate",
  "gradeLabel": "Moderate",
  "claim": "One 60-day, 0.1% periocular study reported hydration and elasticity improvements across the tested molecular weights; wrinkle-depth improvement was limited to the 50 and 130 kDa arms.",
  "caveat": null,
  "published": "2026-09-19",
  "sources": [
    {
      "url": "https://pubmed.ncbi.nlm.nih.gov/22052267/",
      "journal": "J Drugs Dermatol",
      "year": 2011,
      "n": 76,
      "design": "Split-area, vehicle-controlled study",
      "duration": "60 days",
      "percentages": [
        "0.1%"
      ],
      "outcome": "periocular hydration, periocular elasticity, periocular wrinkle depth",
      "finding": "Split-area, vehicle-controlled study in 76 women over 60 days: all five 0.1% periocular hyaluronan preparations improved measured hydration and elasticity versus vehicle; wrinkle-depth improvement was reported only for the 50 and 130 kDa arms. The paper’s penetration explanation is speculative, not a demonstrated outcome.",
      "formulation": "0.1% hyaluronan at 50, 130, 300, 800 or 2,000 kDa"
    }
  ],
  "peopleReport": null
}