Evidence recordApplied to skin
Ceramides
Answer
Studied in relation to a stronger, better-hydrated skin barrier. Part of the skin’s own lipid structure.
Check the formulaEvidence grade
Moderate
Useful human evidence supports the claim, with a meaningful limit in scale, duration, formulation or consistency.
Where it stops
Not stated in this record yet
Sources
Sources · 2
Source 1
Indian J Dermatol, 2023- Design
- Systematic review and meta-analysis of five studies
- Measured outcome
- atopic-dermatitis severity, transepidermal water loss
Finding
Systematic review and meta-analysis in atopic dermatitis, five studies: ceramide-containing moisturisers improved SCORAD against other moisturisers (mean difference -0.98, P=0.003). Transepidermal water loss was NOT significantly different (-3.56, P=0.17, high heterogeneity).
Source 2
J Dermatolog Treat, 2013- Design
- Randomized, investigator-blinded, intra-individual comparison
- Duration
- 4 weeks
- Measured outcome
- transepidermal water loss, dryness, hydration
Finding
Randomised, investigator-blinded, intra-individual comparison in patients with controlled atopic dermatitis: a ceramide-precursor moisturiser on one lower leg against the untreated other leg for 4 weeks gave greater reduction in transepidermal water loss and clinical dryness and higher hydration (all P<.01).