{
  "id": "ceramides",
  "idVersion": 1,
  "ingredient": "Ceramides",
  "route": "topical",
  "grade": "moderate",
  "gradeLabel": "Moderate",
  "claim": "Studied in relation to a stronger, better-hydrated skin barrier. Part of the skin’s own lipid structure.",
  "caveat": null,
  "published": "2026-09-19",
  "sources": [
    {
      "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162745/",
      "journal": "Indian J Dermatol",
      "year": 2023,
      "n": null,
      "design": "Systematic review and meta-analysis of five studies",
      "duration": null,
      "percentages": [],
      "outcome": "atopic-dermatitis severity, transepidermal water loss",
      "finding": "Systematic review and meta-analysis in atopic dermatitis, five studies: ceramide-containing moisturisers improved SCORAD against other moisturisers (mean difference -0.98, P=0.003). Transepidermal water loss was NOT significantly different (-3.56, P=0.17, high heterogeneity).",
      "formulation": null
    },
    {
      "url": "https://pubmed.ncbi.nlm.nih.gov/22812593/",
      "journal": "J Dermatolog Treat",
      "year": 2013,
      "n": null,
      "design": "Randomized, investigator-blinded, intra-individual comparison",
      "duration": "4 weeks",
      "percentages": [],
      "outcome": "transepidermal water loss, dryness, hydration",
      "finding": "Randomised, investigator-blinded, intra-individual comparison in patients with controlled atopic dermatitis: a ceramide-precursor moisturiser on one lower leg against the untreated other leg for 4 weeks gave greater reduction in transepidermal water loss and clinical dryness and higher hydration (all P<.01).",
      "formulation": null
    }
  ],
  "peopleReport": null
}