Evidence recordApplied to skin
Centella asiatica (cica)
Answer
Encouraging early evidence in relation to calmer, more comfortable skin. A long-used soothing botanical.
Check the formulaEvidence grade
Limited
The record is early, small, indirect, mixed or tightly tied to one formulation.
Where it stops
Not stated in this record yet
Sources
Sources · 2
Source 1
Pharmaceutics, 2024- Design
- Review including one split-face, double-blind, placebo-controlled trial
- Reported numbers
- 0.05%
- Measured outcome
- post-laser erythema, collagen synthesis
- Studied formulation
- standardised Centella extract
Finding
Review of topical Centella asiatica. The one controlled human result it reports for erythema is a split-face, double-blind, placebo-controlled trial of 0.05% standardised ECa 233 gel after laser resurfacing for acne scars, in which erythema subsided by day 7 against day 28 on the placebo side (Damkerngsuntorn et al. 2020). The review also describes the actives enhancing collagen synthesis and modulating inflammation.
Source 2
J Ethnopharmacol, 2008- Measured outcome
- wound healing
- Studied formulation
- madecassoside
Finding
Madecassoside facilitated wound healing via antioxidative activity and collagen synthesis (pre-clinical).