{
  "id": "centella",
  "idVersion": 1,
  "ingredient": "Centella asiatica (cica)",
  "route": "topical",
  "grade": "limited",
  "gradeLabel": "Limited",
  "claim": "Encouraging early evidence in relation to calmer, more comfortable skin. A long-used soothing botanical.",
  "caveat": null,
  "published": "2026-09-19",
  "sources": [
    {
      "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510310/",
      "journal": "Pharmaceutics",
      "year": 2024,
      "n": null,
      "design": "Review including one split-face, double-blind, placebo-controlled trial",
      "duration": null,
      "percentages": [
        "0.05%"
      ],
      "outcome": "post-laser erythema, collagen synthesis",
      "finding": "Review of topical Centella asiatica. The one controlled human result it reports for erythema is a split-face, double-blind, placebo-controlled trial of 0.05% standardised ECa 233 gel after laser resurfacing for acne scars, in which erythema subsided by day 7 against day 28 on the placebo side (Damkerngsuntorn et al. 2020). The review also describes the actives enhancing collagen synthesis and modulating inflammation.",
      "formulation": "standardised Centella extract"
    },
    {
      "url": "https://pubmed.ncbi.nlm.nih.gov/18484522/",
      "journal": "J Ethnopharmacol",
      "year": 2008,
      "n": null,
      "design": null,
      "duration": null,
      "percentages": [],
      "outcome": "wound healing",
      "finding": "Madecassoside facilitated wound healing via antioxidative activity and collagen synthesis (pre-clinical).",
      "formulation": "madecassoside"
    }
  ],
  "peopleReport": null
}