MIRU
Evidence recordApplied to skin
Adapalene
Answer
Well studied in relation to clearer skin, most often alongside benzoyl peroxide.
Check the formulaEvidence grade
Strong
Several consistent, relevant sources or an authoritative synthesis support this bounded claim.
Where it stops
Not stated in this record yet
Sources
Sources · 1
Source 1
Cureus, 2024- Design
- Systematic review of eight randomized controlled trials
- Participants
- 4596
- Reported numbers
- 27.5% to 70.2%, 2.7% to 57.9%
- Measured outcome
- acne
- Studied formulation
- adapalene with benzoyl peroxide
Finding
Systematic review of 8 randomised controlled trials, 4,596 participants, compared against vehicle or single-agent treatment: acne lesion reduction ranged from 27.5% to 70.2%, and the review concludes the combination is safe and effective. Adverse effects ranged from 2.7% to 57.9% and were mild.