{
  "id": "adapalene",
  "idVersion": 1,
  "ingredient": "Adapalene",
  "route": "topical",
  "grade": "strong",
  "gradeLabel": "Strong",
  "claim": "Well studied in relation to clearer skin, most often alongside benzoyl peroxide.",
  "caveat": null,
  "published": "2026-09-19",
  "sources": [
    {
      "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472206/",
      "journal": "Cureus",
      "year": 2024,
      "n": 4596,
      "design": "Systematic review of eight randomized controlled trials",
      "duration": null,
      "percentages": [
        "27.5% to 70.2%",
        "2.7% to 57.9%"
      ],
      "outcome": "acne",
      "finding": "Systematic review of 8 randomised controlled trials, 4,596 participants, compared against vehicle or single-agent treatment: acne lesion reduction ranged from 27.5% to 70.2%, and the review concludes the combination is safe and effective. Adverse effects ranged from 2.7% to 57.9% and were mild.",
      "formulation": "adapalene with benzoyl peroxide"
    }
  ],
  "peopleReport": null
}