Ingredient guide
Trifarotene
INCI name · trifarotene
Prescription medicine
Trifarotene is prescribed and followed by a clinician. Your prescriber is the right person for anything about how you are using it.
Start with whoever prescribed it. They hold the plan and the history.
In short
Trifarotene is a prescription topical retinoid approved for acne on the face and trunk in people aged 9 years and older. Two 12-week vehicle-controlled trials support that exact use; they do not establish lower irritation than tretinoin or another retinoid.
What it is
Prescription RAR-gamma-selective retinoid approved as a 0.005% cream for acne on the face and trunk in patients aged 9 years and older; irritation and ultraviolet-exposure precautions apply. Head-to-head tolerability versus tretinoin is not established.
Evidence receipt
StrongTrifarotene (prescription topical) · applied to skin
Based on 2 sources
Open the citable recordTwo 12-week randomized, double-blind, vehicle-controlled phase 3 trials found greater facial and truncal acne improvement with trifarotene 0.005% cream than vehicle.
Studied as Trifarotene (prescription topical): 0.005% trifarotene cream.
Trifarotene is a prescription retinoid. Local irritation and ultraviolet-exposure precautions apply. The trial author list included employees of Galderma R&D, the manufacturer's research organization; neither held source compares trifarotene with another retinoid or establishes adjunctive-treatment benefit.
See 2 sources
Two separate 12-week randomized, double-blind, vehicle-controlled phase 3 trials in patients aged 9 years or older found trifarotene 0.005% cream superior to vehicle on investigator success and inflammatory and non-inflammatory lesion counts on the face and trunk. The author list included employees of Galderma R&D.
facial acne vulgaris, truncal acne vulgaris · 0.005% trifarotene cream
J Am Acad Dermatol, 2019The current U.S. prescribing information, revised October 2023, indicates topical 0.005% trifarotene cream for acne vulgaris on the face and/or trunk in patients aged 9 years and older, and warns about local irritation and ultraviolet exposure. It does not establish superiority or lower irritation versus another retinoid.
U.S. prescribing indication for acne, skin irritation safety, ultraviolet-exposure precautions · 0.005% trifarotene cream
DailyMed prescribing information, 2023
Affiliation note. Publication links report the study authors and their affiliations. MIRU does not infer independence from an affiliation alone.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Trifarotene
- Moisturise
- SPF
Also found as
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Browse product comparisonsCommon questions
What evidence does MIRU hold for trifarotene?
Two randomized, double-blind phase 3 trials found trifarotene 0.005% cream improved facial and truncal acne outcomes versus vehicle over 12 weeks. The author list included employees of Galderma R&D, and the studies did not test another retinoid or adjunctive treatment.
Is trifarotene gentler than tretinoin?
The held sources do not establish that comparison. The prescribing information warns that local irritation can occur and recommends minimizing ultraviolet exposure.
How should trifarotene be considered?
It is a prescription medicine for the face and trunk in people aged 9 years and older. A prescriber should guide its use, including pregnancy questions and irritation.
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Personal guidance, not medical advice.