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Ingredient guide
sh-octapeptide-1
In short
sh‑Octapeptide‑1 is a mimic of keratinocyte growth factor, used to support the skin’s barrier and surface renewal. It helps skin feel stronger and look more even over time.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Firmness · Barrier
Best used
Evening
What it is
Synthetic octapeptide that mimics the receptor-binding region of keratinocyte growth factor (KGF/FGF-7); activates FGFR2b on keratinocytes and sebocytes; KGF signalling supports barrier function, accelerates wound healing, and stimulates epidermal renewal; as a small stable synthetic analogue it overcomes the formulation and regulatory challenges of using intact recombinant KGF protein; used in advanced anti-ageing and barrier recovery serums.
Also found as
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Common questions
It encourages barrier comfort and promotes smoother, healthier‑looking skin.
Most skin types can use it, especially those seeking barrier support and improved texture.
It appears in concentrated serums and is often paired with hydrating or restorative ingredients.
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Personal guidance only · For clinical concerns, see a dermatologist.