Ingredient guide
Hexapeptide-27
INCI name · hexapeptide-27
In short
Hexapeptide‑27 is a synthetic peptide aimed at supporting the skin’s barrier and elasticity. Published data is limited, but it is used in broader signal‑peptide complexes for texture and resilience support.
What it is
Registered PCPC hexapeptide in the higher-numbered sequence; six-amino-acid sequence with skin-conditioning and anti-aging classification; limited published topical data; incorporated into comprehensive signal peptide formulations; part of the emerging registry of hexapeptide actives extending beyond the originally characterised acetyl hexapeptide and lower-number series.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Hexapeptide-27
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does Hexapeptide‑27 do?
It is positioned to help with surface smoothness and general elasticity support, though evidence is still developing.
Which skin types can use Hexapeptide‑27?
It is considered gentle and suitable for dry or sensitive skin.
When is Hexapeptide‑27 used in skincare?
You’ll find it in advanced peptide serums or creams, typically layered after cleansing.
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Personal guidance, not medical advice.