Ingredient guide
Prolyl-Hydroxyproline (Pro-Hyp)
INCI name · PROLYL-HYDROXYPROLINE
In short
Prolyl-Hydroxyproline (Pro-Hyp) is a collagen-derived dipeptide with laboratory findings in cultured human and mouse-skin fibroblasts. MIRU found no human topical outcome trial for this identity, and oral studies of collagen-peptide mixtures do not establish a topical hydration or elasticity benefit.
Best used
Evening
What it is
Collagen-derived dipeptide (Pro-Hyp). Cultured human dermal fibroblasts and mouse-skin fibroblast experiments report fibroblast-proliferation and hyaluronic-acid-synthesis mechanisms. Oral human trials studied collagen-peptide mixtures by a different route, not isolated topical Pro-Hyp. MIRU found no human topical outcome trial for this identity.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Prolyl-Hydroxyproline
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What evidence does MIRU hold for Pro-Hyp?
Laboratory studies report fibroblast-proliferation and hyaluronic-acid-synthesis mechanisms in cultured human dermal fibroblasts and mouse-skin fibroblast experiments. Those non-clinical findings do not show what topical Pro-Hyp does on human skin.
Does topical Pro-Hyp improve hydration or elasticity?
MIRU found no human topical outcome trial for Pro-Hyp itself. It therefore does not turn the laboratory mechanisms into a hydration, elasticity or wrinkle benefit claim.
Do oral collagen studies establish a topical Pro-Hyp benefit?
No. The human studies MIRU reviewed used oral collagen-peptide mixtures with different peptide compositions. A mixed oral product and a different route cannot establish an outcome for isolated topical Pro-Hyp, so this page stays citation-silent for efficacy.
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Personal guidance, not medical advice.