Ingredient guide
Oligopeptide-3 (EGF analogue)
INCI name · oligopeptide-3
In short
Oligopeptide-3 is a lab-made fragment designed to mimic part of epidermal growth factor. It aims to support smoother-looking texture and a firmer feel by encouraging skin cells to stay active. Evidence in finished products is still limited.
What it is
Short synthetic peptide that mimics the receptor-binding domain of epidermal growth factor (EGF); signals through the EGF receptor (EGFR) on keratinocytes and fibroblasts to stimulate proliferation and collagen synthesis; as a small peptide rather than the intact glycoprotein, stability in acidic and neutral formulations is significantly improved; often combined with other growth factor analogues such as sh-oligopeptide-1 for a broader matrix renewal signal.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Oligopeptide-3
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does Oligopeptide-3 do for skin?
It is designed to signal skin cells in a way similar to EGF, helping support a smoother, more elastic appearance. As a small peptide, it is more stable than full EGF in typical skincare formulas.
Who is Oligopeptide-3 best for?
It is often used in formulas targeting fine texture changes or loss of bounce. Most skin types can use it because it is generally well tolerated.
How is Oligopeptide-3 used in routines?
It usually appears in serums or creams meant for daily use. It pairs well with hydrating and barrier-supporting ingredients.
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Personal guidance, not medical advice.