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Ingredient guide
oligopeptide-3
In short
Oligopeptide-3 is a lab-made fragment designed to mimic part of epidermal growth factor. It aims to support smoother-looking texture and a firmer feel by encouraging skin cells to stay active. Evidence in finished products is still limited.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Firmness · Texture
Best used
Evening
What it is
Short synthetic peptide that mimics the receptor-binding domain of epidermal growth factor (EGF); signals through the EGF receptor (EGFR) on keratinocytes and fibroblasts to stimulate proliferation and collagen synthesis; as a small peptide rather than the intact glycoprotein, stability in acidic and neutral formulations is significantly improved; often combined with other growth factor analogues such as sh-oligopeptide-1 for a broader matrix renewal signal.
Also found as
Related
Common questions
It is designed to signal skin cells in a way similar to EGF, helping support a smoother, more elastic appearance. As a small peptide, it is more stable than full EGF in typical skincare formulas.
It is often used in formulas targeting fine texture changes or loss of bounce. Most skin types can use it because it is generally well tolerated.
It usually appears in serums or creams meant for daily use. It pairs well with hydrating and barrier-supporting ingredients.
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Personal guidance only · For clinical concerns, see a dermatologist.