Ingredient guide
Hexapeptide-4
hexapeptide-4
In short
Hexapeptide‑4 is a signalling peptide linked to collagen and elastin support, helping skin look more elastic and smooth. It is often paired with antioxidants or retinoid routines for a complementary effect.
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Works for
Best used
Evening
What it is
Signal peptide with sequence identity to the C-terminal propeptide of procollagen I; the tripeptide K-T-T-K motif interacts with membrane-bound receptors on fibroblasts to upregulate collagen I and elastin synthesis; structurally distinct from palmitoyl pentapeptide-4 (Matrixyl) but overlapping mechanism; useful at 2–5 ppm in serums; pairs well with vitamin C and retinoids for additive elasticity support.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Hexapeptide-4
- Moisturise
- SPF
Also found as
Related
Where to find it
MIRU hasn't verified a catalogue pick that leads with hexapeptide-4yet. The Lens can check any product you're considering.
Search the Lens for hexapeptide-4Common questions
What does Hexapeptide‑4 do?
It supports the look of firmness and elasticity by engaging pathways related to collagen I.
Is Hexapeptide‑4 gentle?
Yes, it is usually well tolerated and works for most skin types.
Where is Hexapeptide‑4 used?
It appears in multi‑peptide serums and moisturisers focused on elasticity support.
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Personal guidance, not medical advice.