Ingredient guide
Hexapeptide-4
INCI name · hexapeptide-4
In short
Hexapeptide‑4 is a signalling peptide linked to collagen and elastin support, helping skin look more elastic and smooth. It is often paired with antioxidants or retinoid routines for a complementary effect.
Works forFrom reviewed ingredient data
Best used
Evening
What it is
Signal peptide with sequence identity to the C-terminal propeptide of procollagen I; the tripeptide K-T-T-K motif interacts with membrane-bound receptors on fibroblasts to upregulate collagen I and elastin synthesis; structurally distinct from palmitoyl pentapeptide-4 (Matrixyl) but overlapping mechanism; useful at 2–5 ppm in serums; pairs well with vitamin C and retinoids for additive elasticity support.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Hexapeptide-4
- Moisturise
- SPF
Also found as
Related
Compare products
Browse product comparisonsCheck a product instead
No verified example is available here. Paste the full ingredient list from a product you are considering for a real verdict.
Check an ingredient listCommon questions
What does Hexapeptide‑4 do?
It supports the look of firmness and elasticity by engaging pathways related to collagen I.
Is Hexapeptide‑4 gentle?
Yes, it is usually well tolerated and works for most skin types.
Where is Hexapeptide‑4 used?
It appears in multi‑peptide serums and moisturisers focused on elasticity support.
Stay in the loop
Get launch updates and occasional product news.
Unsubscribe anytime.
Checking a complete formula? Paste or photograph the ingredient list for the full verdict.
Personal guidance, not medical advice.