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Ingredient guide
hexapeptide-4
In short
Hexapeptide‑4 is a signalling peptide linked to collagen and elastin support, helping skin look more elastic and smooth. It is often paired with antioxidants or retinoid routines for a complementary effect.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Firmness
Best used
Evening
What it is
Signal peptide with sequence identity to the C-terminal propeptide of procollagen I; the tripeptide K-T-T-K motif interacts with membrane-bound receptors on fibroblasts to upregulate collagen I and elastin synthesis; structurally distinct from palmitoyl pentapeptide-4 (Matrixyl) but overlapping mechanism; useful at 2–5 ppm in serums; pairs well with vitamin C and retinoids for additive elasticity support.
Also found as
Related
Common questions
It supports the look of firmness and elasticity by engaging pathways related to collagen I.
Yes, it is usually well tolerated and works for most skin types.
It appears in multi‑peptide serums and moisturisers focused on elasticity support.
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Personal guidance only · For clinical concerns, see a dermatologist.