Ingredient guide
Nicotinoyl Dipeptide-22
INCI name · nicotinoyl dipeptide-22
In short
Nicotinoyl Dipeptide‑22 is a newer biomimetic peptide designed to mimic retinol‑like signalling with a gentler feel. Early data points to support for skin smoothness and brightness.
Skin type
Dry · Sensitive
Best used
Evening
What it is
Biomimetic peptide with a nicotinoyl moiety designed to activate retinol-like signalling pathways without retinoid irritation. Early data suggests collagen-supportive and brightening activity. A newer option for retinol-sensitive routines.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Give these space
The same rules the product checker and routine builder run. Friendly scheduling, not prohibitions.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Nicotinoyl Dipeptide-22
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does Nicotinoyl Dipeptide-22 do?
It aims to encourage smoother texture and a more even look, inspired by retinol pathways.
Is it suitable for sensitive skin?
It was designed with gentleness in mind, making it an option for those who avoid traditional retinoids.
How strong is the evidence?
Research is emerging, with promising but still early-stage data.
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Personal guidance, not medical advice.