Ingredient guide
Lysophosphatidic Acid (LPA, Bioactive Lipid Mediator for Wound Healing & Cell Proliferation)
INCI name · LYSOPHOSPHATIDIC ACID
In short
Lysophosphatidic Acid is a bioactive lipid that signals skin cells to support barrier renewal, firmness, and hydration. It encourages healthy cell turnover and barrier protein production.
Skin type
Dry · Sensitive · Combination
Best used
Evening
What it is
Lysophosphatidic Acid (LPA) is a bioactive glycerophospholipid mediator that signals through G protein-coupled LPA receptors (LPA1-6) expressed on keratinocytes, fibroblasts, and melanocytes; LPA1/LPA2 activation on fibroblasts stimulates cell proliferation, migration, and collagen synthesis. Key wound-healing mediators; LPA3 on keratinocytes promotes differentiation and barrier protein expression (loricrin, involucrin, filaggrin); LPA5 on melanocytes modulates pigmentation signalling; autotaxin (an ectoenzyme on skin surfaces) generates LPA in situ from lysophosphatidylcholine; topical LPA or LPA precursors can supplement endogenous production; anti-apoptotic on skin cells under oxidative stress; inhibits hyaluronic acid degradation; particularly relevant for slow-healing, atrophic, or radiation-damaged skin; present in low concentrations in various plant seed oils; emerging research on topical application for skin renewal and barrier restoration.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Also found as
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Check an ingredient listCommon questions
What does Lysophosphatidic Acid do for skin?
It helps promote barrier resilience, smoother texture, and a firmer appearance by signaling keratinocytes and fibroblasts.
Is Lysophosphatidic Acid suitable for dry or sensitive skin?
Yes, its barrier-supporting and hydration benefits make it a good fit for dry and sensitive skin types.
How is Lysophosphatidic Acid used in skincare?
It is typically added to serums and creams aimed at visible firmness, hydration, and overall barrier comfort.
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Personal guidance, not medical advice.