Ingredient guide
Fisetin
INCI name · fisetin
In short
Fisetin is a fruit‑derived antioxidant flavonol with early‑stage research around skin renewal and redness reduction. Topical use is still emerging, but it offers promising calming and protective potential.
Skin type
Sensitive · Dry · Combination
Best used
Anytime
What it is
Flavonol from strawberries, apples, and persimmon; senolytic activity reported in cell studies via apoptosis induction in p21-positive senescent fibroblasts; directly inhibits PI3K/mTOR and activates AMPK/SIRT1 pathways; potent antioxidant with iron-chelating capacity; anti-inflammatory via NF-κB and MAPK inhibition; topical use is still emerging given interest in seno-targeted skincare; poorly water-soluble, requiring amphiphilic or nanoparticle delivery systems.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Fisetin
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does Fisetin do for skin?
It helps reduce visible redness and supports skin resilience through antioxidant and anti‑stress pathways.
Is Fisetin suitable for sensitive skin?
It may be, but topical formulations are still limited, and evidence is early.
How is Fisetin used?
When included, it’s typically part of advanced antioxidant blends.
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Personal guidance, not medical advice.