Ingredient guide
Fisetin
fisetin
In short
Fisetin is a fruit‑derived antioxidant flavonol with early‑stage research around skin renewal and redness reduction. Topical use is still emerging, but it offers promising calming and protective potential.
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What it is
Flavonol from strawberries, apples, and persimmon; senolytic activity demonstrated in cell studies via apoptosis induction in p21-positive senescent fibroblasts; directly inhibits PI3K/mTOR and activates AMPK/SIRT1 pathways; potent antioxidant with iron-chelating capacity; anti-inflammatory via NF-κB and MAPK inhibition; topical evidence is early-stage given interest in seno-targeted skincare; poorly water-soluble, requiring amphiphilic or nanoparticle delivery systems.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Fisetin
- Moisturise
- SPF
Also found as
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Where to find it
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Search the Lens for fisetinCommon questions
What does Fisetin do for skin?
It helps reduce visible redness and supports skin resilience through antioxidant and anti‑stress pathways.
Is Fisetin suitable for sensitive skin?
It may be, but topical formulations are still limited, and evidence is early.
How is Fisetin used?
When included, it’s typically part of advanced antioxidant blends.
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Personal guidance, not medical advice.