Evidence recordApplied to skin
Palmitoyl Pentapeptide-4 (pal-KTTKS)
Answer
The held evidence is specific to Palmitoyl Pentapeptide-4 (pal-KTTKS), not to peptides as a class.
Check the formulaEvidence grade
Limited
The record is early, small, indirect, mixed or tightly tied to one formulation.
Where it stops
The permeation study used ex-vivo hairless-mouse skin and detected neither KTTKS nor pal-KTTKS in receptor solution. The clinical literature named by the review concerns Palmitoyl Pentapeptide-4 specifically.
Sources
Sources · 2
Source 1
Biomol Ther (Seoul), 2014- Measured outcome
- ex-vivo hairless-mouse skin distribution, dermal stability
- Studied formulation
- KTTKS, palmitoyl-KTTKS
Finding
Ex-vivo full-thickness hairless-mouse skin: neither KTTKS nor pal-KTTKS reached receptor solution. KTTKS was absent from the measured skin layers; pal-KTTKS was detected in stratum corneum and epidermis, with a small dermal amount. This is animal-skin distribution evidence, not human permeation.
Source 2
Cosmetics, 2017- Design
- Narrative review
- Measured outcome
- narrative review of topical peptide treatments
- Studied formulation
- Palmitoyl Pentapeptide-4
Finding
Narrative review names Palmitoyl Pentapeptide-4 as the well-researched molecule and cites Robinson et al. 2005 for a controlled study in photoaged human facial skin. It does not establish a result for peptides as a class.