Evidence recordApplied to skin
Liquiritin
Answer
One small four-week split-face controlled trial in 20 women with epidermal melasma reported improvement with 1% liquiritin cream versus vehicle.
Check the formulaEvidence grade
Limited
The record is early, small, indirect, mixed or tightly tied to one formulation.
Where it stops
This is one small, short study. The PubMed record does not state randomization or blinding, and the study included no hydroquinone or kojic-acid comparator, so it cannot establish comparative tolerability.
Sources
Sources · 1
Source 1
Int J Dermatol, 2000- Design
- Split-face controlled trial
- Participants
- 20
- Duration
- 4 weeks
- Reported numbers
- 1%
- Measured outcome
- epidermal melasma pigmentation
- Studied formulation
- 1% liquiritin cream
Finding
Twenty women with bilateral epidermal melasma used liquiritin cream on one side of the face and vehicle on the other twice daily for four weeks. The report describes improvement with 1% liquiritin, but the PubMed abstract does not state randomization or blinding and names no active comparator.