Ingredient guide
Tripeptide-38 (Syn-Firm)
tripeptide-38
In short
Tripeptide‑38, also known as Matrixyl synthe’6, is a signal peptide that supports firmness, smoothness, and hydration. It encourages multiple components of the skin’s matrix for a more refined surface.
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What it is
Commercially Syn-Firm (Sederma); stimulates neosynthesis of collagen I, collagen III, fibronectin, hyaluronic acid, and decorin in dermal fibroblasts; five-pathway simultaneous induction distinguishes it from single-target signal peptides; clinical data shows measurable firmness improvement in 28-day double-blind studies; pairs well with retinoids and vitamin C for matrix-building protocols.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Tripeptide-38
- Moisturise
- SPF
Also found as
Related
Where to find it
Options across the range, not a ranking. Run one through Lens and MIRU will tell you if it fits you.
StriVectin SD Advanced PLUS Intensive Moisturizing Concentrate
Paula's Choice Pro‑Collagen Multi‑Peptide Booster
Fit comes first: the Lens checks each product against your skin before any retailer link. We may earn a commission, at no cost to you. Picks are editorial, never paid.
Common questions
What does Tripeptide‑38 do for skin?
It helps improve the look of firmness, fine surface lines, and overall smoothness.
Who is Tripeptide‑38 for?
Those seeking a plumper, more resilient appearance may benefit from it.
How is Tripeptide‑38 used?
It’s commonly found in multi‑peptide serums and can be paired with retinoids or vitamin C.
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Personal guidance, not medical advice.