Ingredient guide
Tripeptide-38 (Syn-Firm)
INCI name · tripeptide-38
In short
Tripeptide‑38, also known as Matrixyl synthe’6, is a signal peptide that supports firmness, smoothness, and hydration. It encourages multiple components of the skin’s matrix for a more refined surface.
What it is
Commercially Syn-Firm (Sederma); stimulates neosynthesis of collagen I, collagen III, fibronectin, hyaluronic acid, and decorin in dermal fibroblasts; five-pathway simultaneous induction distinguishes it from single-target signal peptides; clinical data shows measurable firmness improvement in 28-day double-blind studies; pairs well with retinoids and vitamin C for matrix-building protocols.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Tripeptide-38
- Moisturise
- SPF
Also found as
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Common questions
What does Tripeptide‑38 do for skin?
It helps improve the look of firmness, fine surface lines, and overall smoothness.
Who is Tripeptide‑38 for?
Those seeking a plumper, more resilient appearance may benefit from it.
How is Tripeptide‑38 used?
It’s commonly found in multi‑peptide serums and can be paired with retinoids or vitamin C.
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Personal guidance, not medical advice.