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Ingredient guide
tripeptide-38
In short
Tripeptide‑38, also known as Matrixyl synthe’6, is a signal peptide that supports firmness, smoothness, and hydration. It encourages multiple components of the skin’s matrix for a more refined surface.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Firmness · Texture · Hydration
Best used
Evening
What it is
Commercially Syn-Firm (Sederma); stimulates neosynthesis of collagen I, collagen III, fibronectin, hyaluronic acid, and decorin in dermal fibroblasts; five-pathway simultaneous induction distinguishes it from single-target signal peptides; clinical data shows measurable firmness improvement in 28-day double-blind studies; pairs well with retinoids and vitamin C for matrix-building protocols.
Also found as
Related
Where to find it
StriVectin SD Advanced PLUS Intensive Moisturizing Concentrate
Paula's Choice Pro‑Collagen Multi‑Peptide Booster
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Common questions
It helps improve the look of firmness, fine surface lines, and overall smoothness.
Those seeking a plumper, more resilient appearance may benefit from it.
It’s commonly found in multi‑peptide serums and can be paired with retinoids or vitamin C.
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Personal guidance only · For clinical concerns, see a dermatologist.