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Ingredient guide
sh-decapeptide-1
In short
sh‑Decapeptide‑1 is a lab‑made epidermal growth factor analogue that encourages smoother texture and a more elastic feel. It signals skin cells to stay active and maintain surface vitality.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Firmness · Texture
Best used
Evening
What it is
Synthetic peptide modelled on the EGFR-binding domain of epidermal growth factor; signals through EGF receptor to activate downstream RAS/ERK and PI3K/AKT pathways, promoting keratinocyte proliferation and fibroblast activity; as a defined sequence rather than the intact glycoprotein EGF, it is free from batch variation and biosynthetic contamination risk; often present in growth factor cocktail serums alongside sh-oligopeptide-1 and sh-polypeptide-1; supplier studies show fibroblast stimulation in vitro at concentrations above 1 ppb.
Also found as
Related
Common questions
It supports renewal processes that can improve surface smoothness and bounce.
It may appeal to those looking to improve dullness, texture, or early signs of laxity.
It’s usually found in advanced serums and can be layered with hydrating or barrier‑supportive products.
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Personal guidance only · For clinical concerns, see a dermatologist.