Ingredient guide
sh-Decapeptide-1 (EGF analogue)
INCI name · sh-decapeptide-1
In short
sh‑Decapeptide‑1 is a lab‑made epidermal growth factor analogue that encourages smoother texture and a more elastic feel. It signals skin cells to stay active and maintain surface vitality.
What it is
Synthetic peptide modelled on the EGFR-binding domain of epidermal growth factor; signals through EGF receptor to activate downstream RAS/ERK and PI3K/AKT pathways, promoting keratinocyte proliferation and fibroblast activity; as a defined sequence rather than the intact glycoprotein EGF, it is free from batch variation and biosynthetic contamination risk; often present in growth factor cocktail serums alongside sh-oligopeptide-1 and sh-polypeptide-1; supplier studies show fibroblast stimulation in vitro at concentrations above 1 ppb.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- sh-Decapeptide-1
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does sh‑Decapeptide‑1 do for skin?
It supports renewal processes that can improve surface smoothness and bounce.
Who is sh‑Decapeptide‑1 for?
It may appeal to those looking to improve dullness, texture, or early signs of laxity.
How is sh‑Decapeptide‑1 used?
It’s usually found in advanced serums and can be layered with hydrating or barrier‑supportive products.
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Personal guidance, not medical advice.