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Ingredient guide
pentapeptide-5
In short
Pentapeptide‑5, often known as Leuphasyl, is a peptide that helps soften the look of expression lines. It works by influencing signals involved in muscle contraction, giving the surface of the skin a smoother appearance.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Texture · Firmness
Best used
Evening
What it is
Commercially Leuphasyl (Lipotrue/Arch Chemicals); analog of leucine-enkephalin; competitively binds mu-opioid receptors on muscle cells to modulate neurotransmitter release and reduce muscle contraction intensity; softens expression lines by a different mechanism from acetylcholine-blocking peptides like argireline; combination with argireline at 5% each reported to enhance efficacy; suited to forehead and perioral areas.
Also found as
Related
Common questions
It helps reduce the look of expression lines by moderating signals that lead to muscle contraction. This can make forehead and mouth‑area lines appear softer over time.
It suits anyone looking to improve visible expression lines or refine texture, especially around the forehead or mouth. It can be used with other peptides if your skin tolerates layered routines.
It appears in serums or creams designed for line‑softening and texture support. Many formulas pair it with other peptides for a broader smoothing effect.
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Personal guidance only · For clinical concerns, see a dermatologist.