Ingredient guide
Pentapeptide-5 (Leuphasyl)
INCI name · pentapeptide-5
In short
Pentapeptide‑5, often known as Leuphasyl, is a peptide that helps soften the look of expression lines. It works by influencing signals involved in muscle contraction, giving the surface of the skin a smoother appearance.
What it is
Commercially Leuphasyl (Lipotrue/Arch Chemicals); analog of leucine-enkephalin; competitively binds mu-opioid receptors on muscle cells to modulate neurotransmitter release and reduce muscle contraction intensity; softens expression lines by a different mechanism from acetylcholine-blocking peptides like argireline; combination with argireline at 5% each reported to enhance efficacy; suited to forehead and perioral areas.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Pentapeptide-5
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does Pentapeptide‑5 do for skin?
It helps reduce the look of expression lines by moderating signals that lead to muscle contraction. This can make forehead and mouth‑area lines appear softer over time.
Who is Pentapeptide‑5 best for?
It suits anyone looking to improve visible expression lines or refine texture, especially around the forehead or mouth. It can be used with other peptides if your skin tolerates layered routines.
How is Pentapeptide‑5 used in skincare?
It appears in serums or creams designed for line‑softening and texture support. Many formulas pair it with other peptides for a broader smoothing effect.
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Personal guidance, not medical advice.