Ingredient guide
Palmitoyl serine
INCI name · palmitoyl serine
In short
Palmitoyl serine is a lipid‑linked amino acid that helps reinforce the skin’s barrier by integrating into its lipid layers. It supports a smoother, more resilient feel. Research is early but promising for barrier comfort.
Works forFrom reviewed ingredient data
Barrier
Best used
Evening
What it is
N-terminally palmitoylated serine amino acid; lipid-amino acid conjugate that intercalates into the stratum corneum lipid lamellae, contributing to barrier repair in a manner analogous to ceramide precursors; the palmitoyl (C16) chain mirrors the predominant fatty acid species in human skin ceramides, enabling structural integration; studied in combination with phytosphingosine for barrier-deficient skin conditions; well tolerated and stable in anhydrous and low-water formulations.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
When to use it
Evenings suit it best.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Palmitoyl serine
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does palmitoyl serine do for skin?
It helps strengthen the skin’s surface barrier, contributing to improved softness and reduced moisture loss.
Who is palmitoyl serine for?
It is suitable for anyone focusing on barrier support, especially in dry or stressed environments.
How is palmitoyl serine used?
It is typically part of barrier creams and serums and works harmoniously with ceramides and fatty acids.
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Personal guidance, not medical advice.