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Ingredient guide
palmitoyl serine
In short
Palmitoyl serine is a lipid‑linked amino acid that helps reinforce the skin’s barrier by integrating into its lipid layers. It supports a smoother, more resilient feel. Research is early but promising for barrier comfort.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Barrier
Best used
Evening
What it is
N-terminally palmitoylated serine amino acid; lipid-amino acid conjugate that intercalates into the stratum corneum lipid lamellae, contributing to barrier repair in a manner analogous to ceramide precursors; the palmitoyl (C16) chain mirrors the predominant fatty acid species in human skin ceramides, enabling structural integration; studied in combination with phytosphingosine for barrier-deficient skin conditions; well tolerated and stable in anhydrous and low-water formulations.
Also found as
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Common questions
It helps strengthen the skin’s surface barrier, contributing to improved softness and reduced moisture loss.
It is suitable for anyone focusing on barrier support, especially in dry or stressed environments.
It is typically part of barrier creams and serums and works harmoniously with ceramides and fatty acids.
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Personal guidance only · For clinical concerns, see a dermatologist.