Ingredient guide
Lactosyl Ceramide
INCI name · lactosyl ceramide
In short
Lactosyl Ceramide is a naturally occurring skin lipid that helps support barrier organisation. It contributes to keratinocyte signalling and moisture-retaining lipid structures.
What it is
Glycosphingolipid found naturally in the epidermis. Participates in keratinocyte differentiation signalling and lamellar body formation for barrier function.
Evidence receipt
ModerateCeramides · applied to skin
Based on 2 sources
Open the citable recordStudied in relation to a stronger, better-hydrated skin barrier. Part of the skin’s own lipid structure.
See 2 sources
Systematic review and meta-analysis in atopic dermatitis, five studies: ceramide-containing moisturisers improved SCORAD against other moisturisers (mean difference -0.98, P=0.003). Transepidermal water loss was NOT significantly different (-3.56, P=0.17, high heterogeneity).
atopic-dermatitis severity, transepidermal water loss
Indian J Dermatol, 2023Randomised, investigator-blinded, intra-individual comparison in patients with controlled atopic dermatitis: a ceramide-precursor moisturiser on one lower leg against the untreated other leg for 4 weeks gave greater reduction in transepidermal water loss and clinical dryness and higher hydration (all P<.01).
transepidermal water loss, dryness, hydration
J Dermatolog Treat, 2013
Affiliation note. Publication links report the study authors and their affiliations. MIRU does not infer independence from an affiliation alone.
Where it sits
It lives in the moisturiser step, sealing in the lighter layers below.
- Cleanse
- Tone
- Serum
- Lactosyl Ceramide
- SPF
Also found as
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Check an ingredient listCommon questions
What does Lactosyl Ceramide do for skin?
It helps reinforce the barrier by supporting the formation of organised lipid layers that retain moisture.
Who is Lactosyl Ceramide best for?
It suits dry or sensitive skin that benefits from barrier-supportive lipids.
How is Lactosyl Ceramide used?
It’s added to creams or serums focused on replenishing and strengthening the skin’s outer layer.
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