Ingredient guide
Isorhamnetin
INCI name · isorhamnetin
In short
Isorhamnetin is a quercetin‑derived antioxidant with calming and brightening abilities. It can help reduce the look of redness and uneven pigment while offering natural UV‑absorption properties.
Skin type
Sensitive · Combination
Best used
Anytime
What it is
3-methyl ether metabolite of quercetin formed in vivo by COMT-mediated methylation; more lipophilic than parent quercetin, enabling greater membrane permeability in skin cells; direct antioxidant, photoprotective (absorbs UV-A at ~360 nm), and NF-κB inhibitor; inhibits melanogenesis at the transcriptional level by reducing MITF and tyrosinase expression; found in sea-buckthorn and gorse extracts commonly listed in brightening formulations; frequently co-present with quercetin and kaempferol in plant extracts.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Isorhamnetin
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does isorhamnetin do in skincare?
It offers antioxidant protection, helps calm visible redness, and may reduce the look of uneven pigmentation.
Who might use isorhamnetin?
It can suit sensitive or combination skin seeking gentle brightening and environmental support.
How is isorhamnetin used?
It is mainly found in botanical extracts such as sea‑buckthorn, added to serums or moisturisers for antioxidant benefits.
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Personal guidance, not medical advice.