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Ingredient guide
isorhamnetin
In short
Isorhamnetin is a quercetin‑derived antioxidant with calming and brightening abilities. It can help reduce the look of redness and uneven pigment while offering natural UV‑absorption properties.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Redness · Tone
Skin type
Sensitive · Combination
Best used
Anytime
What it is
3-methyl ether metabolite of quercetin formed in vivo by COMT-mediated methylation; more lipophilic than parent quercetin, enabling greater membrane permeability in skin cells; direct antioxidant, photoprotective (absorbs UV-A at ~360 nm), and NF-κB inhibitor; inhibits melanogenesis at the transcriptional level by reducing MITF and tyrosinase expression; found in sea-buckthorn and gorse extracts commonly listed in brightening formulations; frequently co-present with quercetin and kaempferol in plant extracts.
Also found as
Related
Common questions
It offers antioxidant protection, helps calm visible redness, and may reduce the look of uneven pigmentation.
It can suit sensitive or combination skin seeking gentle brightening and environmental support.
It is mainly found in botanical extracts such as sea‑buckthorn, added to serums or moisturisers for antioxidant benefits.
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Personal guidance only · For clinical concerns, see a dermatologist.