Ingredient guide
Hexapeptide-38
INCI name · hexapeptide-38
In short
Hexapeptide‑38 is a barrier‑supporting peptide that helps reinforce the skin’s moisture balance. It supports tight‑junction proteins and surface lipids, helping the skin feel more comfortable and hydrated.
Works forFrom reviewed ingredient data
Barrier · Hydration
Best used
Anytime
What it is
Multi-functional hexapeptide found in skin and scalp formulations; strengthens epidermal barrier function by supporting tight junction and lamellar body protein expression; mild anti-inflammatory secondary effects; compatible with most actives; used in premium moisturisers and barrier-repair products targeting dehydrated or compromised skin.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Hexapeptide-38
- Moisturise
- SPF
Also found as
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Check an ingredient listCommon questions
What does Hexapeptide‑38 do for skin?
It strengthens the skin’s barrier by supporting proteins involved in moisture retention, helping the skin look smoother and feel less dehydrated.
Which skin types can use Hexapeptide‑38?
It is well suited to dry, dehydrated, or easily compromised skin types looking for gentle barrier support.
How is Hexapeptide‑38 used in skincare?
It is often included in moisturisers or hydrating serums aimed at restoring comfort and resilience.
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Personal guidance, not medical advice.