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Ingredient guide
hexapeptide-38
In short
Hexapeptide‑38 is a barrier‑supporting peptide that helps reinforce the skin’s moisture balance. It supports tight‑junction proteins and surface lipids, helping the skin feel more comfortable and hydrated.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Barrier · Hydration
Best used
Anytime
What it is
Multi-functional hexapeptide found in skin and scalp formulations; strengthens epidermal barrier function by supporting tight junction and lamellar body protein expression; mild anti-inflammatory secondary effects; compatible with most actives; used in premium moisturisers and barrier-repair products targeting dehydrated or compromised skin.
Also found as
Related
Common questions
It strengthens the skin’s barrier by supporting proteins involved in moisture retention, helping the skin look smoother and feel less dehydrated.
It is well suited to dry, dehydrated, or easily compromised skin types looking for gentle barrier support.
It is often included in moisturisers or hydrating serums aimed at restoring comfort and resilience.
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Personal guidance only · For clinical concerns, see a dermatologist.