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Ingredient guide
ergothioneine
In short
Ergothioneine is a naturally occurring antioxidant that the skin can actively transport into cells. It helps reduce visible redness and uneven tone while supporting defence against oxidative stress.
Reviewed against published evidence · editorially independent · no brand pays for placement
Works for
Redness · Tone
Skin type
Sensitive · Dry
Best used
Anytime
What it is
Naturally occurring thiohistidine betaine synthesised by fungi and bacteria; actively transported into human cells via the OCTN1 transporter, accumulating in high-UV-exposure tissues including cornea and melanocytes; directly quenches singlet oxygen, peroxynitrite, and hydroxyl radicals at concentrations lower than ascorbic acid equivalents; inhibits melanogenesis by suppressing MITF expression downstream of UV exposure; clinical evidence emerging from topical application trials for UV-induced pigmentation modulation.
Also found as
Related
Where to find it
PCA Skin C&E Advanced
Murad City Skin Overnight Detox Moisturizer
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Common questions
It helps neutralise surface free radicals and supports a more even, calm appearance. It may also help with pigment‑related visible unevenness.
Yes, it is usually well tolerated and can feel calming on dryness‑prone or easily flushed skin.
It is commonly included in antioxidant serums and moisturisers aimed at supporting skin resilience and brightness.
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Personal guidance only · For clinical concerns, see a dermatologist.