Ingredient guide
Ergothioneine
INCI name · ergothioneine
In short
Ergothioneine is a naturally occurring antioxidant that the skin can actively transport into cells. It helps reduce visible redness and uneven tone while supporting defence against oxidative stress.
What it is
Naturally occurring thiohistidine betaine synthesised by fungi and bacteria; actively transported into human cells via the OCTN1 transporter, accumulating in high-UV-exposure tissues including cornea and melanocytes; directly quenches singlet oxygen, peroxynitrite, and hydroxyl radicals at concentrations lower than ascorbic acid equivalents; inhibits melanogenesis by suppressing MITF expression downstream of UV exposure; clinical evidence emerging from topical application trials for UV-induced pigmentation modulation.
Evidence receipt
No linked study yet
No verified study is linked to this exact ingredient and route. The guidance below describes conventional use; it is not evidence of efficacy.
Where it sits
Serums sit after toner and before moisturiser. Thinnest to thickest, water before oil.
- Cleanse
- Tone
- Ergothioneine
- Moisturise
- SPF
Also found as
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Common questions
What does ergothioneine do for skin?
It helps neutralise surface free radicals and supports a more even, calm appearance. It may also help with pigment‑related visible unevenness.
Is ergothioneine good for sensitive skin?
Yes, it is usually well tolerated and can feel calming on dryness‑prone or easily flushed skin.
How is ergothioneine used?
It is commonly included in antioxidant serums and moisturisers aimed at supporting skin resilience and brightness.
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Personal guidance, not medical advice.