{
  "id": "trifarotene",
  "idVersion": 1,
  "ingredient": "Trifarotene (prescription topical)",
  "route": "topical",
  "grade": "strong",
  "gradeLabel": "Strong",
  "claim": "Two 12-week randomized, double-blind, vehicle-controlled phase 3 trials found greater facial and truncal acne improvement with trifarotene 0.005% cream than vehicle.",
  "caveat": "Trifarotene is a prescription retinoid. Local irritation and ultraviolet-exposure precautions apply. The trial author list included employees of Galderma R&D, the manufacturer's research organization; neither held source compares trifarotene with another retinoid or establishes adjunctive-treatment benefit.",
  "published": "2026-09-19",
  "sources": [
    {
      "url": "https://pubmed.ncbi.nlm.nih.gov/30802558/",
      "journal": "J Am Acad Dermatol",
      "year": 2019,
      "n": null,
      "design": "Randomized, double-blind, vehicle-controlled phase 3 trials",
      "duration": "12 weeks",
      "percentages": [
        "0.005%"
      ],
      "outcome": "facial acne vulgaris, truncal acne vulgaris",
      "finding": "Two separate 12-week randomized, double-blind, vehicle-controlled phase 3 trials in patients aged 9 years or older found trifarotene 0.005% cream superior to vehicle on investigator success and inflammatory and non-inflammatory lesion counts on the face and trunk. The author list included employees of Galderma R&D.",
      "formulation": "0.005% trifarotene cream"
    },
    {
      "url": "https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=62d910db-85a6-4696-b69b-4bd2f3080cfc",
      "journal": "DailyMed prescribing information",
      "year": 2023,
      "n": null,
      "design": null,
      "duration": null,
      "percentages": [
        "0.005%"
      ],
      "outcome": "U.S. prescribing indication for acne, skin irritation safety, ultraviolet-exposure precautions",
      "finding": "The current U.S. prescribing information, revised October 2023, indicates topical 0.005% trifarotene cream for acne vulgaris on the face and/or trunk in patients aged 9 years and older, and warns about local irritation and ultraviolet exposure. It does not establish superiority or lower irritation versus another retinoid.",
      "formulation": "0.005% trifarotene cream"
    }
  ],
  "peopleReport": null
}