{
  "id": "snail-mucin",
  "idVersion": 1,
  "ingredient": "Snail Secretion Filtrate",
  "route": "topical",
  "grade": "limited",
  "gradeLabel": "Limited",
  "claim": "One small placebo-controlled trial found fewer inflammatory lesions with a three-ingredient serum containing snail secretion filtrate.",
  "caveat": "The serum also contained calendula and licorice, so the effect cannot be attributed to snail secretion filtrate alone. Non-inflammatory lesions and measured skin biophysics did not differ; a 2024 review found most wider claims rest on preclinical or small clinical studies.",
  "published": "2026-09-19",
  "sources": [
    {
      "url": "https://pubmed.ncbi.nlm.nih.gov/35763437/",
      "journal": "J Cosmet Dermatol",
      "year": 2022,
      "n": 66,
      "design": "Randomized double-blind placebo-controlled trial",
      "duration": "12 weeks",
      "percentages": [],
      "outcome": "inflammatory acne lesions, non-inflammatory acne lesions, sebum, corneometry, transepidermal water loss, erythema",
      "finding": "Twelve-week randomized double-blind placebo-controlled trial in 66 people with mild-to-moderate mask-related acne: the three-ingredient serum reduced inflammatory lesions more than placebo, while non-inflammatory lesions and measured skin biophysics did not significantly differ. Snail secretion filtrate was not tested alone.",
      "formulation": "snail secretion filtrate, calendula and licorice serum, placebo serum"
    },
    {
      "url": "https://pubmed.ncbi.nlm.nih.gov/38429932/",
      "journal": "J Cosmet Dermatol",
      "year": 2024,
      "n": null,
      "design": "Literature review",
      "duration": null,
      "percentages": [],
      "outcome": "clinical evidence limitations, allergy investigation, ethical extraction",
      "finding": "Literature review of medical and cosmetic uses: most studies were preclinical or small clinical studies, and larger clinical trials are needed to support claimed benefits and clarify safety and ethical-extraction questions.",
      "formulation": "snail mucin and snail extract preparations"
    }
  ],
  "peopleReport": null
}