{
  "id": "panthenol",
  "idVersion": 1,
  "ingredient": "Panthenol (pro-vitamin B5)",
  "route": "topical",
  "grade": "moderate",
  "gradeLabel": "Moderate",
  "claim": "Studied in relation to soothed, better-hydrated skin. A gentle barrier supporter.",
  "caveat": null,
  "published": "2026-09-19",
  "sources": [
    {
      "url": "https://pubmed.ncbi.nlm.nih.gov/12113650/",
      "journal": "Am J Clin Dermatol",
      "year": 2002,
      "n": null,
      "design": null,
      "duration": null,
      "percentages": [],
      "outcome": "stratum-corneum hydration, barrier function",
      "finding": "Topical dexpanthenol acts as a humectant and barrier enhancer, increasing stratum-corneum hydration.",
      "formulation": null
    },
    {
      "url": "https://doi.org/10.1080/09546634.2016.1214235",
      "journal": "J Dermatolog Treat",
      "year": 2017,
      "n": null,
      "design": "Two randomized controlled trials",
      "duration": null,
      "percentages": [],
      "outcome": "hydration, barrier restoration",
      "finding": "Two RCTs: panthenol emollient improved hydration and barrier-restoration vs control.",
      "formulation": "panthenol emollient"
    }
  ],
  "peopleReport": null
}