{
  "id": "kttks",
  "idVersion": 1,
  "ingredient": "KTTKS (Lys-Thr-Thr-Lys-Ser)",
  "route": "topical",
  "grade": "limited",
  "gradeLabel": "Limited",
  "claim": "The held evidence is an ex-vivo stability and distribution study of the exact KTTKS sequence in hairless-mouse skin.",
  "caveat": "Unmodified KTTKS was absent from every measured skin layer and from receptor solution. The Palmitoyl Pentapeptide-4 clinical literature does not transfer to KTTKS.",
  "published": "2026-09-19",
  "sources": [
    {
      "url": "https://pubmed.ncbi.nlm.nih.gov/25143811/",
      "journal": "Biomol Ther (Seoul)",
      "year": 2014,
      "n": null,
      "design": null,
      "duration": null,
      "percentages": [],
      "outcome": "ex-vivo hairless-mouse skin distribution, dermal stability",
      "finding": "Ex-vivo full-thickness hairless-mouse skin: neither KTTKS nor pal-KTTKS reached receptor solution. Unmodified KTTKS was absent from the measured skin layers, while pal-KTTKS was detected in stratum corneum and epidermis with a small dermal amount. This does not establish human permeation or a clinical effect for KTTKS.",
      "formulation": "KTTKS, palmitoyl-KTTKS"
    }
  ],
  "peopleReport": null
}